Water → N-allyl-5-azaisatin

HRID 1756560ノート

反応式

HRID 1756560 の反応式
[CH2:1]([N:4]1[C:10](=O)[O:9][C:7](=[O:8])[C:6]2=[CH:12][N:13]=[CH:14][CH:15]=[C:5]12)[CH:2]=[CH2:3].[C-]#N.[K+].O>CN(C=O)C>[CH2:1]([N:4]1[C:5]2[C:6](=[CH:12][N:13]=[CH:14][CH:15]=2)[C:7](=[O:8])[C:10]1=[O:9])[CH:2]=[CH2:3]

参加物

5

反応物 3

HCID 962WaterHCID 9032Potassium CyanideHCID 86595201N-allyl-5-azaisatoic anhydride

生成物 1

HCID 19390720N-allyl-5-azaisatin

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

反応条件

温度
100 °C

実験手順

A solution of N-allyl-5-azaisatoic anhydride (20 mmol) in DMF is added dropwise to a suspension of pulverized potassium cyanide (21 mmol) in DMF at 100° C. The reaction mixture is stirred at 100° C. for an additional 5 min after which time the mixture is poured into cold water and extracted with ether. The organic layer is dried (Na2SO4), filtered and the solvent is removed. Stirring the resulting residue in 2N hydrochloric acid overnight and adjusting the pH to 7 gives, upon filtration, N-allyl-5-azaisatin.

後処理

  1. extractionextracted with ether
  2. dry with materialThe organic layer is dried (Na2SO4)
  3. filtrationfiltered
  4. customthe solvent is removed
  5. stirringStirring the resulting residue in 2N hydrochloric acid overnight

出典と根拠

ORDレコード
ord-e134912baed44531ba06493a8a2a91dc
出典データセット
uspto-grants-1995_08
特許番号
US05441955

反応ノート

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