Amino-1-(3-iodophenyl)-benzimidazole → 2-Amino-1-[3-(3-hydroxymethyl-4-thienyl)-phenyl]-benzimidazole

HRID 1756639ノート

反応式

HRID 1756639 の反応式
[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9](I)[CH:8]=2)[C:5]2[CH:14]=[CH:15][CH:16]=[CH:17][C:4]=2[N:3]=1.[OH:18][CH2:19][C:20]1[C:21](B(O)O)=[CH:22][S:23][CH:24]=1>>[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:21]3[C:20]([CH2:19][OH:18])=[CH:24][S:23][CH:22]=3)[CH:8]=2)[C:5]2[CH:14]=[CH:15][CH:16]=[CH:17][C:4]=2[N:3]=1

参加物

3

反応物 2

HCID 19390960Amino-1-(3-iodophenyl)-benzimidazoleHCID 19390961(4-(Hydroxymethyl)thiophen-3-yl)boronic acid

生成物 1

HCID 193909832-Amino-1-[3-(3-hydroxymethyl-4-thienyl)-phenyl]-benzimidazole収率 56%

実験手順

2-Amino-1-[3-(3-hydroxymethyl-4-thienyl)-phenyl]-benzimidazole was synthesized as above with amino-1-(3-iodophenyl)-benzimidazole and 4-hydroxymethyl-3-thienylboronic acid as starting materials. Yield 56%, mp. 106°-108° C.

出典と根拠

ORDレコード
ord-d7d5482b94f94d5ba0f1d98b8ef7d33f
出典データセット
uspto-grants-1995_08
特許番号
US05441969

反応ノート

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