Piperidine → 1-Acetyl-4-(4-piperidinobenzoylmethyl)piperidine

HRID 1756673ノート

反応式

HRID 1756673 の反応式
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][C:11](=[O:19])[C:12]2[CH:17]=[CH:16][C:15](F)=[CH:14][CH:13]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[NH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>C(=O)([O-])O.[Na+]>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][C:11](=[O:19])[C:12]2[CH:17]=[CH:16][C:15]([N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:14][CH:13]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 8082PiperidineHCID 100841181-Acetyl-4-(4-fluorobenzoylmethyl)piperidine

生成物 1

HCID 193909281-Acetyl-4-(4-piperidinobenzoylmethyl)piperidine

試薬・触媒・溶媒 1

HCID 516892Sodium Bicarbonate溶媒

反応条件

温度
100 °C

実験手順

A mixture consisting of 1.84 g of 1-acetyl-4-(4-fluorobenzoylmethyl)piperidine and 5 ml of piperidine was stirred under heating at 100° C. for 20 hours. After completion of the reaction, the reaction mixture was diluted with a saturated aqueous solution of sodium hydrogen carbonate and extracted with ethyl acetate. After drying, the solvent was ditilled off and the oily residue was purified by silica gel column chromatography (eluent: ehtyl acetate) to give 2.2 g of a pale yellow oil.

後処理

  1. customAfter completion of the reaction
  2. extractionextracted with ethyl acetate
  3. customAfter drying
  4. customthe oily residue was purified by silica gel column chromatography (eluent: ehtyl acetate)

出典と根拠

ORDレコード
ord-9d6aadc167794ea09ea4f0c49476e436
出典データセット
uspto-grants-1995_08
特許番号
US05441967

反応ノート

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