4-(Methylthio)aniline → N-[4-(Methylsulfanyl)phenyl]urea

HRID 1756690ノート

反応式

HRID 1756690 の反応式
[CH3:1][S:2][C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1.[O-:10][C:11]#[N:12].[Na+]>C(O)(=O)C.O>[CH3:1][S:2][C:3]1[CH:9]=[CH:8][C:6]([NH:7][C:11]([NH2:12])=[O:10])=[CH:5][CH:4]=1

参加物

5

反応物 2

HCID 660384-(Methylthio)anilineHCID 517096Sodium Cyanate

生成物 1

HCID 306638N-[4-(Methylsulfanyl)phenyl]urea収率 96.8%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒2 回

実験手順

A solution of 30 g (170 mmol) of 4-(methylmercapto)aniline dissolved in 83 ml of acetic acid and 165 ml of water was heated to 40° C. Once warmed to 40° C. a solution of sodium cyanate (22.2 g; 340 mmol) in 150 ml of water was slowly added. The resulting suspension was stirred for 15 minutes and then allowed to sit for 2 hours. Filtration of the suspension provided 29.98 g of title compound. m.p. 155°-159° C.

後処理

  1. additionwas slowly added
  2. waitto sit for 2 hours
  3. filtrationFiltration of the suspension

出典と根拠

ORDレコード
ord-5a859bdb13594bed8f802d6f1328b913
出典データセット
uspto-grants-1995_08
特許番号
US05441984

反応ノート

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