Hydrochloric Acid → (E)-2-(Hydroxyimino)-N-methyl-2-(2-phenoxyphenyl)acetamide

HRID 1756742

反応式

HRID 1756742 の反応式
[NH2:1][OH:2].[CH3:3][NH:4][C:5](=[O:21])[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=O.Cl>C1(C)C=CC=CC=1>[CH3:3][NH:4][C:5](=[O:21])/[C:6](/[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[N:1]/[OH:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 787HydroxylamineHCID 11780091N-methyl-2-(2-phenoxyphenyl)-2-oxoacetamide

生成物 1

HCID 9816878(E)-2-(Hydroxyimino)-N-methyl-2-(2-phenoxyphenyl)acetamide収率 98%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Toluene (20 ml) and a 50% aqueous solution (0.71 ml, 12 mmol) of hydroxylamine were added to N-methyl-2-(2-phenoxyphenyl)-2-oxoacetamide (2.55 g, 10 mmol). The mixture was heated under reflux for 4 hours (E/Z=40/60). After cooling, conc. hydrochloric acid (3.0 ml, 30 mmol) was added, and the mixture was stirred at room temperature for 24 hours. After completion of the reaction, the resulting crystals were separated by filtration, washed with water and toluene and dried to give (E)-N-methyl-2-(2-phenoxyphenyl)-2-hydroxyiminoacetamide (2.65 g, Yield: 98.0%, E/Z=98/2).

後処理

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 4 hours (E/Z=40/60)
  3. temperatureAfter cooling
  4. customAfter completion of the reaction
  5. customthe resulting crystals were separated by filtration
  6. washwashed with water and toluene
  7. customdried

出典と根拠

ORDレコード
ord-3bd77effff06463a86bad3004dca5749
出典データセット
uspto-grants-1995_08
特許番号
US05442063

関連ノート

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