Bromomethyl 4-methoxyphenyl ketone → HCID 23371609、化合物
反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH2:8][CH2:9][C:10](=[O:13])[NH:11][N:12]=2)=[CH:3][CH:2]=1.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]([CH2:24][Br:25])=[O:23])=[CH:18][CH:17]=1>C(O)C>[Br-:25].[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]([CH2:24][N+:1]2[CH:6]=[CH:5][C:4]([C:7]3[CH2:8][CH2:9][C:10](=[O:13])[NH:11][N:12]=3)=[CH:3][CH:2]=2)=[O:23])=[CH:18][CH:17]=1参加物
4
実験手順
4,5-Dihydro-6-(4-pyridyl)-pyridazin-3(2H)-one (175 mg, 1 mmol) and 4'-methoxyphenacyl bromide (252 mg, 1.1 mmol) were dissolved in absolute ethanol (5 ml), refluxed for two hours and then stirred at room temperature overnight. The resulting precipitate was collected by filtration and washed with absolute ethanol to obtain the titled compound (350 mg) as brown columns.