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Hydrochloric Acid → 4-Dimethylaminobenzyl alcohol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-(Dimethylamino)Benzaldehyde | HCID 7479 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Dimethylaminobenzyl alcohol | HCID 137166 | — |
反応手順
Mix 4-dimethylaminobenzaldehyde (3.3 g, 22 mmol), sodium borohydride (830mg, 22 mmol) and absolute ethanol (25 mL). Stir at room temperature until the reaction is complete, pour onto dilute hydrochloric acid and extract into ethyl acetate. Separate the organic phase and extract the aqueous phase with ethyl acetate (2×). Combine the organic phases and dry (MgSO4). Evaporate the solvent in vacuo and purify by silica gel chromatography to give 4-(dimethylamino)benzyl alcohol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05446068 |
| 出典データセット | uspto-grants-1995_08 |
| ORD ID | ord-1e00f12ae83842a6ba338e94c3133aa7 |
| 出典メモ | uspto-grants-1995_08 |