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Hydrochloric Acid → 5-(3,4-Dimethoxy-6-chlorophenyl)-2,4-pentadienoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-Chloro-4,5-dimethoxybenzaldehyde | HCID 279351 | — |
| 反応物 | Ethyl trans-crotonate | HCID 429065 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 5-(3,4-Dimethoxy-6-chlorophenyl)-2,4-pentadienoic acid | HCID 54056704 | — |
反応手順
To a solution containing 10.0 g 3,4 dimethoxy-6-chlorobenzaldehyde and 8 mlof ethyl crotonate in 60 ml of N-methylpyrrolidone 6.0 g of potassium tert.-butoxide was added while stirring. The solution was stirred for 0.5 h more at 20° C. and poured then to a mixture of ice and hydrochloric acid. The solution was extracted with ether. The ether solution was washed with water and extracted with 2.5 N NaOH-solution. Theaqueous phase was acidified with hydrochloric acid and the semisolid product was separated. Yield 10.8 g (81%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05446194 |
| 出典データセット | uspto-grants-1995_08 |
| ORD ID | ord-146b028085bc4eb38cf81ae63f26544a |
| 出典メモ | uspto-grants-1995_08 |