Dimethylformamide → Methyl 4-phenylthiazolylcyanoacetate

HRID 1758126ノート

反応式

HRID 1758126 の反応式
[CH2:1]([S:10][C:11]#[N:12])[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=O.CN(C=O)C.C(N(CC)CC)C.[C:25]([CH2:27][C:28]([O:30][CH3:31])=[O:29])#[N:26]>C(O)(=O)C.O>[C:4]1([C:2]2[N:12]=[C:11]([CH:27]([C:25]#[N:26])[C:28]([O:30][CH3:31])=[O:29])[S:10][CH:1]=2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

7

反応物 4

HCID 6228DimethylformamideHCID 7747Methyl cyanoacetateHCID 8471TriethylamineHCID 219693Phenacyl thiocyanate

生成物 1

HCID 20510873Methyl 4-phenylthiazolylcyanoacetate

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

実験手順

90 parts of phenacyl thiocyanate are introduced into a mixture of 150 parts of DMF, 150 parts of triethylamine and 50 parts of methyl cyanoacetate. The mixture is then stirred for 4 hours at room temperature, after which it is introduced into water and the batch is acidified with acetic acid. The product which precipitates is filtered off and dried in an oven.

後処理

  1. customThe product which precipitates
  2. filtrationis filtered off
  3. customdried in an oven

出典と根拠

ORDレコード
ord-3f94c4b018504dd88e8ccd7a2d6cdbc3
出典データセット
uspto-grants-1983_02
特許番号
US04371734

反応ノート

読み込み中…