Acetone → HCID 178473693、化合物

HRID 1758303ノート

反応式

HRID 1758303 の反応式
[SH:1][C:2]1[NH:6][N:5]=[N:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:13][C:14]([CH3:16])=[O:15]>>[C:14]([CH2:16][S:1][C:2]1[NH:6][N:5]=[N:4][N:3]=1)(=[O:15])[CH3:13]

参加物

4

反応物 3

HCID 180AcetoneHCID 11430Potassium CarbonateHCID 178527994HCID 178527994、化合物

生成物 1

HCID 178473693HCID 178473693、化合物

実験手順

5-Mercapto-1,2,3,4-tetrazole (1 g), potassium carbonate (2 g) and β-chloroacetone (1.4 g) are added to acetone (50 ml) and the solution is refluxed with stirring for 2 hours. The reaction mixture is concentrated to dryness under reduced pressure and the residue is dissolved in chloroform. Insolubles are filtered off and the filtrate is concentrated under reduced pressure. The residue is purified by silica gel column chromatography (Kieselgel 60, eluant: benzene-ether (10:1) to obtain 5-acetylmethylthio-1,2,3,4-tetrazole (0.4 g) as colorless liquid.

後処理

  1. temperaturethe solution is refluxed
  2. concentrationThe reaction mixture is concentrated to dryness under reduced pressure
  3. dissolutionthe residue is dissolved in chloroform
  4. filtrationInsolubles are filtered off
  5. concentrationthe filtrate is concentrated under reduced pressure
  6. customThe residue is purified by silica gel column chromatography (Kieselgel 60, eluant

出典と根拠

ORDレコード
ord-c7e52f44d55c4e29bfb4f06df1b9487d
出典データセット
uspto-grants-1983_02
特許番号
US04372953

反応ノート

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