化工社化工社 化学情報印刷レポート · 研究参考用
Formaldehyde → Tetrahydro-N-(2-hydroxyethyl)-N-(phosphonomethyl)-3-thiophenamine 1,1-dioxide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Phosphorous acid | HCID 107909 | — |
| 反応物 | 2-[(1,1-Dioxidotetrahydro-3-thienyl)amino]ethanol hydrochloride | HCID 16896370 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Tetrahydro-N-(2-hydroxyethyl)-N-(phosphonomethyl)-3-thiophenamine 1,1-dioxide | HCID 20509043 | 61.9% |
反応手順
A solution of tetrahydro-N-hydroxymethyl-3-thiophenamine 1,1-dioxide hydrochloride of Example 3 (21.5 parts, 0.1 mole); 90 percent paraformaldehyde (3.7 parts, 0.11 mole); 70 percent aqueous orthophosphorous acid (12.9 parts, 0.11 mole); and water (6.0 parts) was heated at its reflux temperature for 3 hours. The product could not be isolated as a filterable solid due to its hygroscopic nature. The solution containing 61.9 percent of the title compound was used for testing without any further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04374040 |
| 出典データセット | uspto-grants-1983_02 |
| ORD ID | ord-ff1a9a38b8764641845768319570b3c8 |
| 出典メモ | uspto-grants-1983_02 |