Methylamine → N-[2-(2-methylamino-2-phenylethyl)phenyl]-2,2-dimethylpropanamide
反応式
Cl[CH:2]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13].[CH3:23][NH2:24]>CC(O)C>[CH3:23][NH:24][CH:2]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13]参加物
4
反応条件
- 温度
- 80 °C
実験手順
N-[2-(2-chloro-2-phenylethyl)phenyl]-2,2-dimethylpropanamide (1.0 g, 3.17 mol) was reacted with monomethyl amine (7 g of 40% aqueous solution) in 2-propanol (3 g). The mixture was heated to 80° C. and stirred for 1 hour. Formation of product was indicated by TLC (silica gel/70 ethyl acetate/30 methanol).