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Ethyl isocyanate → 6-[[(Ethylamino)carbonyl]-amino]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl isocyanate | HCID 8022 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 6-Amino-4-hydroxyquinoline-3-carboxylic acid | HCID 3281201 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 6-[[(Ethylamino)carbonyl]-amino]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 13106337 | — |
反応手順
A mixture of 4.08 g (20 mmol) of 6-amino-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid [J. Pharm. Sci., 11, 1051 (1963)] 2.37 ml (30 mmol) of ethyl isocyanate, 2.8 ml (20 mmol) of triethylamine and 50 ml of dimethylformamide is stirred at room temperature overnight. The solution is evaporated to dryness and the residue is treated with 1 N hydrochloric acid. The solid is filtered to give 4.56 g of 6-[[(ethylamino)carbonyl]-amino]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, mp>320° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04374138 |
| 出典データセット | uspto-grants-1983_02 |
| ORD ID | ord-19a0b53de0654a1690ffa7d0681a309a |
| 出典メモ | uspto-grants-1983_02 |