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Cysteamine Hydrochloride → 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cysteamine Hydrochloride | HCID 9082 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | (2-((Dimethylamino)methyl)thiazol-4-yl)methanol | HCID 1838020 | — |
| 反応物 | N-{[4-(chloromethyl)-1,3-thiazol-2-yl]methyl}-N,N-dimethylamine | HCID 1967272 | — |
| 生成物 | 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole | HCID 10977318 | — |
反応手順
When 2-dimethylaminomethyl-4-hydroxymethylthiazole [prepared in Step D] is reacted with thionyl chloride and the resultant 2-dimethylaminomethyl-4-chloromethylthiazole is reacted with an equimolar amount of cysteamine hydrochloride and two equivalents of base according to the general procedure of Example 33, Step D, the title compound is thereby produced.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04374248 |
| 出典データセット | uspto-grants-1983_02 |
| ORD ID | ord-9b01a9765cd14379bccfde5360abe53e |
| 出典メモ | uspto-grants-1983_02 |