5-Aminoimidazole-4-carboxamide hydrochloride → 4-(2-Thienyl)imidazo[1,5-a]pyrimidine-8-carboxamide

HRID 1758794ノート

反応式

HRID 1758794 の反応式
C[N:2]([CH3:12])[CH:3]=[CH:4][C:5]([C:7]1[S:8][CH:9]=[CH:10][CH:11]=1)=O.Cl.NC1[N:16]=[CH:17][NH:18][C:19]=1[C:20]([NH2:22])=[O:21].C([O-])(=O)C.[Na+]>C(O)(=O)C>[S:8]1[CH:9]=[CH:10][CH:11]=[C:7]1[C:5]1[N:16]2[CH:17]=[N:18][C:19]([C:20]([NH2:22])=[O:21])=[C:12]2[N:2]=[CH:3][CH:4]=1

参加物

5

反応物 3

HCID 661465-Aminoimidazole-4-carboxamide hydrochlorideHCID 517045Sodium AcetateHCID 6023993-(Dimethylamino)-1-(2-thienyl)-2-propen-1-one

生成物 1

HCID 205089574-(2-Thienyl)imidazo[1,5-a]pyrimidine-8-carboxamide

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 0.01 mol of 3-dimethylamino-1-(2-thienyl)-2-propen-1-one (prepared as described in Example 1, Part A), 0.01 mol of 4amino-5-imidazolecarboxamide hydrochloride and 0.01 mol of anhydrous sodium acetate in 25 ml. of glacial acetic acid can be refluxed for 16 hours. The reaction mixture can be cooled and the crystalline precipitate collected by filtration and washed with water to produce 4-(2-thienyl)imidazo[1,5-a]pyrimidine-8-carboxamide.

後処理

  1. customprepared
  2. temperatureThe reaction mixture can be cooled
  3. filtrationthe crystalline precipitate collected by filtration
  4. washwashed with water

出典と根拠

ORDレコード
ord-aead6c4625aa4cd5aa47356fb23eea00
出典データセット
uspto-grants-1983_02
特許番号
US04374988

反応ノート

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