2-Azaspiro[5.5]undec-1-ene → 2-Azaspiro[5.5]undecane

HRID 1758810ノート

反応式

HRID 1758810 の反応式
[CH:1]1[C:6]2([CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][N:2]=1.[H][H]>[Ni].C(O)C>[CH2:1]1[C:6]2([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]2)[CH2:5][CH2:4][CH2:3][NH:2]1

参加物

5

反応物 2

HCID 18835922-Azaspiro[5.5]undec-1-eneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 50061172-Azaspiro[5.5]undecane収率 88.1%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

A solution of 2-azaspiro-[5.5]-undec-1-ene (15 g.; 0.10 mole) and one teaspoon (3 g.) of W2 Raney nickel catalyst in absolute ethanol (300 ml.) is hydrogenated at an initial pressure of 40 psi until hydrogen uptake ceases (2 hours). The mixture is filtered through celite and the filtrate concentrated under reduced pressure. Distillation of the residual liquid yields 88% of 2-azaspiro-[5.5]-undecane (13.5 g.), b.p. 55°-57° C./C.10 mm.

後処理

  1. filtrationThe mixture is filtered through celite
  2. concentrationthe filtrate concentrated under reduced pressure
  3. distillationDistillation of the residual liquid

出典と根拠

ORDレコード
ord-ad75773f035f4f9c9d27151c877806ac
出典データセット
uspto-grants-1983_02
特許番号
US04374991

反応ノート

読み込み中…