2-Amino-5-(trifluoromethyl)pyridine → 1-(2-Chloro-6-fluorobenzoyl)-3-(5-trifluoromethyl-2-pyridinyl)urea

HRID 1758926ノート

反応式

HRID 1758926 の反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][C:6]([NH2:9])=[N:7][CH:8]=1.[Cl:12][C:13]1[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[C:14]=1[C:15]([N:17]=[C:18]=[O:19])=[O:16]>>[Cl:12][C:13]1[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[C:14]=1[C:15]([NH:17][C:18]([NH:9][C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:10])[F:11])=[CH:8][N:7]=1)=[O:19])=[O:16]

参加物

3

反応物 2

HCID 7358622-Amino-5-(trifluoromethyl)pyridineHCID 130517312-Chloro-6-fluorobenzoyl isocyanate

生成物 1

HCID 205331381-(2-Chloro-6-fluorobenzoyl)-3-(5-trifluoromethyl-2-pyridinyl)urea

実験手順

A portion of 5-trifluoromethyl-2-aminopyridine is reacted with 2-chloro-6-fluorobenzoyl isocyanate as described in Example 1. The reaction mixture is evaporated under vacuum and the product is recrystallized to obtain the product named above.

後処理

  1. customThe reaction mixture is evaporated under vacuum
  2. customthe product is recrystallized
  3. customto obtain the product

出典と根拠

ORDレコード
ord-b8eb3f1f637c4e79a5ec9277707eb4d3
出典データセット
uspto-grants-1982_07
特許番号
US04338321

反応ノート

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