Phosphorus oxychloride → 2-(6-Chloro-3-pyridazinyl)phenol

反応式

[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[CH:10][C:11](=O)[NH:12][N:13]=1.P(Cl)(Cl)([Cl:17])=O>>[Cl:17][C:11]1[N:12]=[N:13][C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[OH:1])=[CH:9][CH:10]=1

参加物

反応物 2

HCID 24813Phosphorus oxychloride

HCID 30173466-(2-Hydroxyphenyl)-3(2H)-pyridazinone

生成物 1

HCID 30187332-(6-Chloro-3-pyridazinyl)phenol

実験手順

According to the process of this invention, a 6-(2-hydroxyphenyl)-3(2H)-pyridazinone is reacted with phosphorus oxychloride and a disubstituted formamide to give a 3-chloro-6-(2-hydroxyphenyl)pyridazine. ##STR1## The term R is hydrogen or lower alkyl.

出典と根拠

ORDレコード: ord-ec3316e960f4429a9157d0d6b48c8fe0
出典データセット: uspto-grants-1982_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04340733

反応ノート

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