1,1-Diphenylacetone → 3-Diphenylmethyl-2,3,6,7-tetrahydro-6,6-dimethyl-5H-thiazolo[3,2-a]pyrimidin-3-ol hydrobromide

HRID 1759374

反応式

HRID 1759374 の反応式
[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8](=[O:10])[CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:17]CC(=O)C(C1C=CC=CC=1)C1C=CC=CC=1.[CH3:34][C:35]1([CH3:42])[CH2:40][NH:39][C:38](=[S:41])[NH:37][CH2:36]1>CC(C)=O>[BrH:17].[C:11]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8]2([OH:10])[N:39]3[CH2:40][C:35]([CH3:42])([CH3:34])[CH2:36][N:37]=[C:38]3[S:41][CH2:9]2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

参加物

5

反応物 3

HCID 699071,1-DiphenylacetoneHCID 27946353-Bromo-1,1-diphenylacetone2 回HCID 38664875,5-Dimethyl-1,4,5,6-tetrahydro-pyrimidine-2-thiol

生成物 1

HCID 155712123-Diphenylmethyl-2,3,6,7-tetrahydro-6,6-dimethyl-5H-thiazolo[3,2-a]pyrimidin-3-ol hydrobromide

試薬・触媒・溶媒 1

HCID 180Acetone溶媒2 回

実験手順

A 2.1 g. portion of 1,1-diphenyl-2-propanone is converted to 1-bromo-3,3-diphenyl-2-propanone as described in Example 22. This 1-bromo-3,3-diphenyl-2-propanone is dissolved in 15 ml. of acetone and added to a boiling mixture of 1.0 g. of tetrahydro-5,5-dimethyl-2(1H)-pyrimidinethione in 50 ml. of acetone. The mixture is allowed to stand at room temperature for 24 hours and the resulting solid is collected by filtration, giving the desired product, m.p. 259°-261° C.

後処理

  1. filtrationthe resulting solid is collected by filtration

出典と根拠

ORDレコード
ord-74b9700bce794469a10ff051d82ec604
出典データセット
uspto-grants-1982_07
特許番号
US04340734

関連ノート

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