Benzoyl chloride → 3-Chloro-2,2,3-trifluoro-propionyl chloride

HRID 1759583ノート

反応式

HRID 1759583 の反応式
[Cl:1][CH:2]([F:9])[C:3]([F:8])([F:7])[C:4](O)=[O:5].C([Cl:18])(=O)C1C=CC=CC=1>>[Cl:1][CH:2]([F:9])[C:3]([F:8])([F:7])[C:4]([Cl:18])=[O:5]

参加物

3

反応物 2

HCID 7412Benzoyl chlorideHCID 205313223-Chloro-2,2,3-trifluoropropanoic acid

生成物 1

HCID 141224163-Chloro-2,2,3-trifluoro-propionyl chloride

実験手順

In a three-necked 2 l flask provided with a Vigreux column, a condenser, and a collecting flask were brought 325 g (2 moles) of 3-chloro-2,2,3-trifluoro-propionic acid (Org.Synth.Coll. 5, 239) and 562 g (4 moles) of benzoyl chloride. The mixture was heated so that the acid chloride distilled over slowly. The collected product was refluxed for 20 min to eliminate any residual hydrochloric acid. Finally the product was distilled at normal pressure. Yield: 280 g. Boiling point: 72°-74° C.

後処理

  1. customIn a three-necked 2 l flask provided with a Vigreux column, a condenser, and a collecting flask
  2. distillationdistilled over slowly
  3. temperatureThe collected product was refluxed for 20 min
  4. distillationFinally the product was distilled at normal pressure

出典と根拠

ORDレコード
ord-c436943872e143dca8a6cbf920ea371e
出典データセット
uspto-grants-1982_07
特許番号
US04341864

反応ノート

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