Hydrochloric Acid → HCID 22821046、化合物
反応式
[ClH:1].C(OC([NH:9][CH2:10][C:11]([NH:13][C@H:14]([C:22]([NH:24][CH3:25])=[O:23])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:12])=O)(C)(C)C>CO>[ClH:1].[NH2:9][CH2:10][C:11]([NH:13][C@H:14]([C:22]([NH:24][CH3:25])=[O:23])[CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[O:12]参加物
4
実験手順
Gaseous HCl is bubbled through a solution of t-boc-gly-phe-NHCH3 8a (9.2 g, 2.7×10-2 mole) and methanol (200 ml). After 1/2 hour the methanol is evaporated at reduced pressure leaving a clear colorless oil which, when triturated with Et2O crystallizes to give 9a as a colorless power: m.p. 220°-223° C. In a similar fashion, gly-phe-leu-NHEt.HCl is prepared from its corresponding t-boc-derivative.
後処理
- customAfter 1/2 hour the methanol is evaporated at reduced pressure
- customleaving a clear colorless oil which, when
- customtriturated with Et2O
- customcrystallizes
出典と根拠
- ORDレコード
- ord-2e9e9e6074ea45feb081b24f4f8197e8
- 出典データセット
- uspto-grants-1982_07
- 特許番号
- US04341698
反応ノート
読み込み中…