2-Acetyl-5-iodothiophene → HCID 20531515、化合物

HRID 1759632

反応式

HRID 1759632 の反応式
IC1SC(C(=O)C)=CC=1.[C:10]([C:12]1[S:16][C:15]([C:17](=[O:19])[CH3:18])=[CH:14][CH:13]=1)#[N:11]>>[C:17]([C:15]1[S:16][C:12]([CH2:10][NH2:11])=[CH:13][CH:14]=1)(=[O:19])[CH3:18]

参加物

3

反応物 2

HCID 965692-Acetyl-5-iodothiopheneHCID 27475655-Acetylthiophene-2-carbonitrile

生成物 1

HCID 20531515HCID 20531515、化合物

実験手順

Starting with the readily available compound, denoted 2, 5-iodo-2-acetylthiophene ##STR2## and using a procedure described by S. Nishimura and E. Imoto, Nippon Kagaku Zasshi 82, 1411 (1961), incorporated by reference herein, one generates 5-cyano-2-acetylthiophene denoted 3 below, ##STR3## The "blocked" form is then generated according to standard methods. See for example W. S. Johnson et al., J. Amer. Chem. Soc. 78, 6300, (1956), incorporated by reference herein. This results in a compound, denoted 4 below, ##STR4## Compound 4 is then reduced with available methods such as the one described by R. F. Nystrom and W. G. Brown, J. Amer. Chem. Soc. 70, 3738 (1948), incorporated by reference herein, and then "deblocked" (see for example W. S. Johnson et al. above) to give 2-acetyl-5-(aminomethyl)thiophene, 5,: ##STR5## Then using standard Claisen condensation techniques, such as described by J. C. Reid and M. Calvin, J. Amer. Chem. Soc. 72, 2948 (1950), incorporated by reference herein, the chelating ligand 1 is synthesized, abbreviated hereafter as TTFA-NH2.

後処理

  1. customThis results in a compound

出典と根拠

ORDレコード
ord-3c53afc2278a4470934a9747cd049c23
出典データセット
uspto-grants-1982_07
特許番号
US04341957

関連ノート

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