Cyclohexylamine → Ethyl 5-amino-6-cyclohexylaminonicotinate

HRID 1760272ノート

反応式

HRID 1760272 の反応式
Cl[C:2]1[C:12]([N+:13]([O-])=O)=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][N:3]=1.[CH:16]1([NH2:22])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>CS(C)=O.O>[NH2:13][C:12]1[C:2]([NH:22][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[N:3][CH:4]=[C:5]([CH:11]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7]

参加物

5

反応物 2

HCID 7965CyclohexylamineHCID 3784053Ethyl 6-chloro-5-nitronicotinate

生成物 1

HCID 22598045Ethyl 5-amino-6-cyclohexylaminonicotinate収率 74%

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

実験手順

Ethyl 6-chloro-5-nitronicotinate (1.00 g, 4.33 mmol) prepared according to A. H. Berrie et al. (J. Chem. Soc. 1951, 2590) was dissolved in DMSO (2 mL) and cyclohexylamine (0.54 g, 5.4 mmol) was added. The mixture was stirred for 1 h at room temperature, diluted with water and the yellow precipitate collected by filtration. The product was washed with water and dried (0.95 g, 74% yield).

後処理

  1. filtrationthe yellow precipitate collected by filtration
  2. washThe product was washed with water
  3. customdried (0.95 g, 74% yield)

出典と根拠

ORDレコード
ord-e1e930e1f67d41cfb65e936e1c86166c
出典データセット
uspto-grants-2005_01
特許番号
US06841566B2

反応ノート

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