Dimethyl Sulfoxide → Anisole, m-pentadecyl-

HRID 1760278

反応式

HRID 1760278 の反応式
CS(C)=O.[CH2:5]([C:20]1[CH:21]=[C:22]([OH:26])[CH:23]=[CH:24][CH:25]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19].[OH-].[K+].[CH3:29]I>O>[CH2:5]([C:20]1[CH:21]=[C:22]([O:26][CH3:29])[CH:23]=[CH:24][CH:25]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 68146Hydrogenated cardanol

生成物 1

HCID 578947Anisole, m-pentadecyl-収率 99.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Into a 2-liter round-bottomed flask was placed 500 milliliters (ml) of dimethyl sulfoxide, 100 grams (g) of 3-(n-pentadecyl)phenol (0.33 mol), and 73.55 g of potassium hydroxide (1.31 mol). To this mixture, 93.5 g of methyl iodide ( 0.66 mol) was added drop wise with stirring at room temperature. After the addition, the reaction mixture was stirred for a further 6 hours. Then the reaction mixture was poured into deionized water (1.5 liters). The organic material was extracted by addition of diethyl ether. The diethyl ether layer was separated, washed with water, dried over anhydrous sodium sulfate, and finally evaporated to afford the crude product as a viscous fluid. This material was purified by silica gel column chromatography using petroleum ether as the eluent to furnish 3-(n-pentadecyl) anisole (104.6 g, 97% of theoretical yield) having a melting range of 27-28° C.

後処理

  1. customInto a 2-liter round-bottomed flask was placed
  2. additionAfter the addition
  3. stirringthe reaction mixture was stirred for a further 6 hours
  4. extractionThe organic material was extracted by addition of diethyl ether
  5. customThe diethyl ether layer was separated
  6. washwashed with water
  7. dry with materialdried over anhydrous sodium sulfate
  8. customfinally evaporated
  9. customto afford the crude product as a viscous fluid
  10. customThis material was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-3cf97b5fcb6f4f77939273e9fdc3f3a5
出典データセット
uspto-grants-2005_01
特許番号
US06841598B2

関連ノート

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