化工社化工社 化学情報印刷レポート · 研究参考用
3-Cyclopropyl-3-oxopropanenitrile → Quinoline-2-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Cyclopropyl-3-oxopropanenitrile | HCID 9812763 | — |
| 反応物 | 2-Amino-4'-fluorobenzophenone | HCID 9837287 | — |
| 生成物 | Quinoline-2-carbonitrile | HCID 74031 | — |
反応手順
The cyclization reaction step of the present invention is a step of reacting 3-cyclopropyl-3-oxopropanenitrile of the formula (1) with 2-amino-4′-fluorobenzophenone of the formula (2) preferably in the presence of an acid to obtain a quinolinecarbonitrile derivative [2-cyclopropyl-4-(4′-fluorophenyl)quinoline-3-carbonitrile] of the formula (3).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06841681B2 |
| 出典データセット | uspto-grants-2005_01 |
| ORD ID | ord-fcb79a81fc7d4ba79d80b4b37e899127 |
| 出典メモ | uspto-grants-2005_01 |