Lithium Hexamethyldisilazide → 7-(1-Ethyl-propoxy)-1,5-dimethyl-3-(2,4,6-trimethyl-phenyl)-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

反応式

[CH2:1]([CH:3]([O:6][C:7]1[CH:12]=[C:11]([CH3:13])[N:10]=[C:9]2[N:14]([C:18]3[C:23]([CH3:24])=[CH:22][C:21]([CH3:25])=[CH:20][C:19]=3[CH3:26])[C:15](=[O:17])[NH:16][C:8]=12)[CH2:4][CH3:5])[CH3:2].[CH3:27][Si]([N-][Si](C)(C)C)(C)C.[Li+]>>[CH2:1]([CH:3]([O:6][C:7]1[CH:12]=[C:11]([CH3:13])[N:10]=[C:9]2[N:14]([C:18]3[C:19]([CH3:26])=[CH:20][C:21]([CH3:25])=[CH:22][C:23]=3[CH3:24])[C:15](=[O:17])[N:16]([CH3:27])[C:8]=12)[CH2:4][CH3:5])[CH3:2]

参加物

反応物 2

HCID 2733832Lithium Hexamethyldisilazide

HCID 21912303HCID 21912303、化合物

生成物 1

HCID 219120937-(1-Ethyl-propoxy)-1,5-dimethyl-3-(2,4,6-trimethyl-phenyl)-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

実験手順

The title compound was prepared by reacting 7-(1-ethyl-propoxy)-5-methyl-3-(2,4,6-trimethyl-phenyl)-1,3-dihydro-imidazo[4,5-b]pyridin-2-one with lithium bis(trimethylsilyl)amide, followed by quenching with methyl iodide. Mp. 151-153° C. Anal. For C22H2N3O2. 1/4H2O calc. C, 71.03; H, 7.99; N, 11.30; found: C, 71.29; H, 8.01; N, 11.03.

後処理

customby quenching with methyl iodide

出典と根拠

ORDレコード: ord-610d9a84930b4a64b45f5a6b7068eed9
出典データセット: uspto-grants-2005_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06844351B1

反応ノート

読み込み中…