Ethyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butanoate → 4-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)butanoic acid
反応式
[N:1]1[C:10]2[NH:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][C:2]=1[CH2:11][CH2:12][CH2:13][C:14]([O:16]CC)=[O:15]>Cl>[N:1]1[C:10]2[NH:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][C:2]=1[CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15]参加物
3
反応条件
- 温度
- 55 °C
実験手順
The ester obtained in Step b (0.36 g; 1.45 mmol) is dissolved in 10 ml of 6N HCl. The reaction mixture is heated at 55° C. for 4 hours. The reaction mixture is then concentrated, and the residue is taken up in AcOEt. The resulting precipitate, corresponding to the title product, is suction-filtered off over a frit and isolated in the form of a pale yellow solid.
後処理
- concentrationThe reaction mixture is then concentrated
- filtrationThe resulting precipitate, corresponding to the title product, is suction-filtered off over a frit
- customisolated in the form of a pale yellow solid
出典と根拠
- ORDレコード
- ord-d3017aeab6e24f4faa34700fa15ce092
- 出典データセット
- uspto-grants-2005_01
- 特許番号
- US06846833B2
反応ノート
読み込み中…