Methylamine → N-methyl benzothiophene-2-carboxamide

関与物質

反応手順

To a stirred solution of 2.0 M methylamine in THF (60 mL) and THF (60 mL) was added dropwise at 0° C. a solution of benzothiophene-2-carbonyl chloride (10.8 g, 55 mmole) in THF (50 mL) over 15 minutes. After the addition the reaction was allowed to warm to RT then was concentrated under vacuum. Trituration with a cold solution of 4:1H2Q/methanol (50 mL), filtration, and drying under vacuum gave the title compound (10.35 g. 98%) as a white solid: MS (ES) m/e 191.9 (M+H)+.

情報源と証拠