Oxindole → 3-[(4-Methylthiophen-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one
反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[CH3:11][C:12]1[CH:13]=[C:14]([CH:17]=O)[S:15][CH:16]=1>N1CCCCC1.C(O)C>[CH3:11][C:12]1[CH:13]=[C:14]([CH:17]=[C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][C:2]2=[O:10])[S:15][CH:16]=1参加物
5
反応条件
- 温度
- 90 °C
実験手順
A reaction mixture of 133.0 mg of oxindole, 151.2 mg of the 4-methylthiophene-2-carboxaldehyde, and 3 drops of piperidine in 3 mL of ethanol was stirred at 90° C. for 3 h. After cooling, the precipitate was filtered, washed with cold ethanol, and dried to yield 147.3 mg (61%) of the title compound as a yellow solid.
後処理
- temperatureAfter cooling
- filtrationthe precipitate was filtered
- washwashed with cold ethanol
- customdried
出典と根拠
- ORDレコード
- ord-974b62aaf1e345dca220ffda5645d043
- 出典データセット
- uspto-grants-2005_01
- 特許番号
- US06846839B1
反応ノート
読み込み中…