5-Methyl-2-thiophenecarboxaldehyde → 3-[(2-Methylthien-5-yl)methylene]-2-indolinone

HRID 1761152ノート

反応式

HRID 1761152 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[CH3:11][C:12]1[S:16][C:15]([CH:17]=O)=[CH:14][CH:13]=1>N1CCCCC1.C(O)C>[CH3:17][C:15]1[S:16][C:12]([CH:11]=[C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][C:2]2=[O:10])=[CH:13][CH:14]=1

参加物

5

反応物 2

HCID 616635-Methyl-2-thiophenecarboxaldehydeHCID 321710Oxindole

生成物 1

HCID 43748903-[(2-Methylthien-5-yl)methylene]-2-indolinone収率 99%

試薬・触媒・溶媒 2

HCID 8082Piperidine触媒HCID 702Ethanol溶媒

反応条件

温度
90 °C

実験手順

A reaction mixture of 134.0 mg of oxindole, 151.42 mg of the 5-methylthiophene-2-carboxaldehyde, and 3 drops of piperidine in 2 mL of ethanol was stirred at 90° C. for 3 h. After cooling, the precipitate was filtered, washed with cold ethanol, and dried to yield 237.8 mg (99%) of the title compound as a yellow solid.

後処理

  1. temperatureAfter cooling
  2. filtrationthe precipitate was filtered
  3. washwashed with cold ethanol
  4. customdried

出典と根拠

ORDレコード
ord-bf95c1848cbf490f8c91319b88cfe7e3
出典データセット
uspto-grants-2005_01
特許番号
US06846839B1

反応ノート

読み込み中…