Acetic Acid → 110714-14-2
反応式
[N:1]1([C:6]2[N:11]=[N:10][C:9](Cl)=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.C(O)(=[O:15])C>>[N:1]1([C:6]2[CH:7]=[CH:8][C:9](=[O:15])[NH:10][N:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1参加物
3
実験手順
9.93 g (0.055 mole) of 6-(1-imidazolyl)-3-chloropyridazine [prepared according to J. Med. Chem. 24, 59 (1981)] are boiled with 7.7 g (0.0781 mole) of fused potassium acetate in 114 ml of acetic acid under reflux for 10 hours and then evaporated to dryness under reduced pressure. The residue is taken up in 200 ml of chloroform, the precipitate is filtered off, washed 4 times with water, then with ether and diisopropyl ether and dried to give 4.9 g (55% yield) of the aimed product, m. p. 239°-240° C.
後処理
- temperatureunder reflux for 10 hours
- customevaporated to dryness under reduced pressure
- filtrationthe precipitate is filtered off
- washwashed 4 times with water
- dry with materialwith ether and diisopropyl ether and dried
出典と根拠
- ORDレコード
- ord-63859f0fee8a463687f86b608effa81c
- 出典データセット
- uspto-grants-1989_05
- 特許番号
- US04826845
反応ノート
読み込み中…