Acetone → HCID 21241555、化合物

HRID 1761410ノート

反応式

HRID 1761410 の反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=O)[CH2:5]2.[CH3:12][C:13]([CH3:15])=O.N>C(O)C>[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH2:6][C:5]2=[C:13]([CH3:15])[CH3:12]

参加物

5

反応物 3

HCID 180AcetoneHCID 222AmmoniaHCID 769555-Hydroxyoxindole

生成物 1

HCID 21241555HCID 21241555、化合物収率 94%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 20 g. 5-hydroxyindolinone, 80 ml. acetone and 80 ml. ethanol is saturated with gaseous ammonia and heated under reflux for 3 hours. After evaporation, the reaction mixture is filtered off with suction. There are obtained 27.7 g. of the title compound (94% of theory); m.p. 235° C.

後処理

  1. additionA mixture of 20 g
  2. temperatureheated
  3. temperatureunder reflux for 3 hours
  4. customAfter evaporation
  5. filtrationthe reaction mixture is filtered off with suction
  6. customThere are obtained 27.7 g

出典と根拠

ORDレコード
ord-c01383028bd44e71a6d0380fc43bd347
出典データセット
uspto-grants-1989_05
特許番号
US04826847

反応ノート

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