7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine → HCID 21241318、化合物
反応式
[CH3:1][O-:2].[Na+].Cl[C:5]1[N:10]2[N:11]=[CH:12][N:13]=[C:9]2[N:8]=[C:7]([CH3:14])[CH:6]=1>CO>[CH3:1][O:2][C:5]1[N:10]2[N:11]=[CH:12][N:13]=[C:9]2[N:8]=[C:7]([CH3:14])[CH:6]=1参加物
4
実験手順
A 28% methanol solution of sodium methoxide, 2.52 g, is diluted with 50 ml of dry methanol To this, 2.00 g of 7-chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine is added at room temperature and stirred for 30 minutes. The solvent is evaporated under reduced pressure and the residue is treated with water and extracted twice with dichloromethane. The combined extract is washed with saline and dried over anhydrous potassium carbonate. Evaporation of the solvent under reduced pressure gives 1.69 g of the desired compound as colorless crystals.
後処理
- additionis added at room temperature
- customThe solvent is evaporated under reduced pressure
- additionthe residue is treated with water
- extractionextracted twice with dichloromethane
- extractionThe combined extract
- washis washed with saline
- dry with materialdried over anhydrous potassium carbonate
- customEvaporation of the solvent under reduced pressure
出典と根拠
- ORDレコード
- ord-c3d5bfc9aadd4fd0812780a285db81e8
- 出典データセット
- uspto-grants-1989_05
- 特許番号
- US04826834
反応ノート
読み込み中…