Ipriflavone → Ipriflavon gamma-cyclodextrin

HRID 1761629

反応式

HRID 1761629 の反応式
[CH3:1][CH:2]([O:4][C:5]1[CH:6]=[CH:7][C:8]2[C:14](=[O:15])[C:13]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)=[CH:12][O:11][C:9]=2[CH:10]=1)[CH3:3].[CH2:22]([OH:108])[C@H:23]1[O:28][C@@H:27]2[O:29][C@H:30]3[C@H:35]([OH:36])[C@@H:34]([OH:37])[C@@H:33]([O:38][C@H:39]4[C@H:44]([OH:45])[C@@H:43]([OH:46])[C@@H:42]([O:47][C@H:48]5[C@H:53]([OH:54])[C@@H:52]([OH:55])[CH:51]([O:56][CH:57]6[C@H:62]([OH:63])[C@@H:61]([OH:64])[CH:60]([CH:65]7[C@H:70]([OH:71])[C@@H:69]([OH:72])[CH:68]([O:73][C@H:74]8[C@H:79]([OH:80])[C@@H:78]([OH:81])[C@@H:77]([O:82][C@H:83]9[C@H:89]([OH:90])[C@@H:88]([OH:91])[C@@H:86]([O:87][C@H:24]1[C@H:25]([OH:107])[C@H:26]2[OH:106])[O:85][C@@H:84]9[CH2:92][OH:93])[O:76][C@@H:75]8[CH2:94][OH:95])[O:67][C@@H:66]7[CH2:96][OH:97])[O:59][C@@H:58]6[CH2:98][OH:99])[O:50][C@@H:49]5[CH2:100][OH:101])[O:41][C@@H:40]4[CH2:102][OH:103])[O:32][C@@H:31]3[CH2:104][OH:105]>>[CH3:3][CH:2]([O:4][C:5]1[CH:6]=[CH:7][C:8]2[C:14](=[O:15])[C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:12][O:11][C:9]=2[CH:10]=1)[CH3:1].[CH2:22]([OH:108])[C@H:23]1[O:28][C@@H:27]2[O:29][C@H:30]3[C@H:35]([OH:36])[C@@H:34]([OH:37])[C@@H:33]([O:38][C@H:39]4[C@H:44]([OH:45])[C@@H:43]([OH:46])[C@@H:42]([O:47][C@H:48]5[C@H:53]([OH:54])[C@@H:52]([OH:55])[CH:51]([O:56][CH:57]6[C@H:62]([OH:63])[C@@H:61]([OH:64])[CH:60]([CH:65]7[C@H:70]([OH:71])[C@@H:69]([OH:72])[CH:68]([O:73][C@H:74]8[C@H:79]([OH:80])[C@@H:78]([OH:81])[C@@H:77]([O:82][C@H:83]9[C@H:89]([OH:90])[C@@H:88]([OH:91])[C@@H:86]([O:87][C@H:24]1[C@H:25]([OH:107])[C@H:26]2[OH:106])[O:85][C@@H:84]9[CH2:92][OH:93])[O:76][C@@H:75]8[CH2:94][OH:95])[O:67][C@@H:66]7[CH2:96][OH:97])[O:59][C@@H:58]6[CH2:98][OH:99])[O:50][C@@H:49]5[CH2:100][OH:101])[O:41][C@@H:40]4[CH2:102][OH:103])[O:32][C@@H:31]3[CH2:104][OH:105]

参加物

3

反応物 2

HCID 3747Ipriflavone2 回HCID 44431027gamma-Cyclodextrine

生成物 1

HCID 131715936Ipriflavon gamma-cyclodextrin

実験手順

0.5 g (1.78 mmoles) of Ipriflavon were dissolved in 50 ml of 96% ethanol and the solutions thus obtained was added dropwise to the solution of 8.0 g (5.35 mmoles) of γ-cyclodextrin of 13.3% moisture content in 50 ml of distilled water, during 2 hours, then the mixture left to cool to room temperature. After a further 16-hour intensive stirring the product obtained was filtered and dried for 24 hours at 60° C. to give 5.5 g of product. Ipriflavon content: 7.9% by weight, molar ratio of Ipriflavon:γ-cyclodextrin=1:2.29. Yield related to the active ingredient: 87%. The product also contains free cyclodextrin.

後処理

  1. customYield

出典と根拠

ORDレコード
ord-b84b808ef9df42aa9f0e55c46e457abf
出典データセット
uspto-grants-1989_05
特許番号
US04826963

関連ノート

読み込み中…