Acetic Anhydride → N-(3-Chloro-4-fluorophenyl)acetamide
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[F:9])[NH2:5].[C:10](OC(=O)C)(=[O:12])[CH3:11]>O>[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][C:10](=[O:12])[CH3:11])[CH:6]=[CH:7][C:8]=1[F:9]参加物
4
実験手順
To 3-chloro-4-fluoroaniline (100 g) was slowly added acetic anhydride (200 ml). After allowed to stand for 30 minutes, the reaction mixture was poured into water (1 litter). The resulting precipitate was collected by filtration and recrystallized from aqueous ethanol to give the title compound (119.4 g), mp 118°-119° C.
後処理
- filtrationThe resulting precipitate was collected by filtration
- customrecrystallized from aqueous ethanol
出典と根拠
- ORDレコード
- ord-5e5001753cee4cfdbeb924443d6973e6
- 出典データセット
- uspto-grants-1989_05
- 特許番号
- US04826982
反応ノート
読み込み中…