N-(5-chloro-4-fluoro-2-nitrophenyl)acetamide → 5-Chloro-4-fluoro-2-nitroaniline

HRID 1761642ノート

反応式

HRID 1761642 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH:12]C(=O)C)[C:5]([N+:9]([O-:11])=[O:10])=[CH:6][C:7]=1[F:8]>Cl.C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]([N+:9]([O-:11])=[O:10])=[CH:6][C:7]=1[F:8])[NH2:12]

参加物

4

反応物 1

HCID 2773811N-(5-chloro-4-fluoro-2-nitrophenyl)acetamide

生成物 1

HCID 5178355-Chloro-4-fluoro-2-nitroaniline収率 101.3%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 702Ethanol溶媒

実験手順

A solution of N-(3-chloro-4-fluoro-6-nitrophenyl)acetamide (30 g) in concentrated hydrochloric acid (50 ml) and ethanol (200 ml) was refluxed for 2.5 hours. To the reaction mixture was added ice water (300 ml) and the resulting precipitate was collected by filtration, washed with water and dried to give the title compound (24.9 g) as yellow needles, mp 149.5°-150° C.

後処理

  1. filtrationthe resulting precipitate was collected by filtration
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-5910cdfdf8d448a4a349dea5664d92e6
出典データセット
uspto-grants-1989_05
特許番号
US04826982

反応ノート

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