Sulfuric Acid → 3-Bromo-2,4,5-trifluorobenzoic acid

HRID 1761647ノート

反応式

HRID 1761647 の反応式
[Br:1][C:2]1[C:3]([F:13])=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5](N)=[O:6].S(=O)(=O)(O)[OH:15]>>[Br:1][C:2]1[C:3]([F:13])=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5]([OH:15])=[O:6]

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 137488013-Bromo-2,4,5-trifluorobenzamide

生成物 1

HCID 27832463-Bromo-2,4,5-trifluorobenzoic acid

反応条件

温度
100 °C

実験手順

A mixture of 3-bromo-2,4,5-trifluorobenzamide (8.7 g) and 18N-sulfuric acid (50 ml) was stirred at 100° C. for 4 hours, and then poured into ice water (200 ml). The resulting precipitate was collected by filtration and recrystallized from dichloro-methane-n-hexane to give the title compound (6.9 g), mp 125°-127° C.

後処理

  1. filtrationThe resulting precipitate was collected by filtration
  2. customrecrystallized from dichloro-methane-n-hexane

出典と根拠

ORDレコード
ord-1740de5887144befa7cbdfabb2cab21c
出典データセット
uspto-grants-1989_05
特許番号
US04826982

反応ノート

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