Hydroxide → 4-Hydroxy-4'-methoxybiphenyl

HRID 1761658ノート

反応式

HRID 1761658 の反応式
C([C:4]1[C:5]([OH:17])=[CH:6][C:7]2C[CH2:9][CH2:10][CH:11]([CH2:14][CH2:15][CH3:16])[C:12]=2[CH:13]=1)(=O)C.[OH-].S(OC)([O:22][CH3:23])(=O)=O>>[CH3:23][O:22][C:16]1[CH:9]=[CH:10][C:11]([C:12]2[CH:13]=[CH:4][C:5]([OH:17])=[CH:6][CH:7]=2)=[CH:14][CH:15]=1

参加物

4

反応物 3

HCID 961HydroxideHCID 6497Dimethyl SulfateHCID 212421503-Acetyl-5-propyl-5,6,7,8-tetrahydro-2-naphthol

生成物 1

HCID 110308394-Hydroxy-4'-methoxybiphenyl

実験手順

4,4'-Dihydroxydiphenyl (1) (32 g 0.17 mol) was dissolved in 2M solution hydroxide solution (0.34 mol) and dimethyl sulphate (22 g 0.175 mol) was added slowly with stirring over half an hour. The sodium salt of the required product was filtered off and dried. The yield was 24 g. The sodium salt of the phenol (24 g) was treated with acetyl chloride (150 cm3), filtered and excess acetyl chloride removed. Work up gave 4- methoxy-4'-acetoxydiphenyl (4) (22 g).

後処理

  1. additionwas added slowly
  2. filtrationThe sodium salt of the required product was filtered off
  3. customdried
  4. additionThe sodium salt of the phenol (24 g) was treated with acetyl chloride (150 cm3)
  5. filtrationfiltered
  6. customexcess acetyl chloride removed

出典と根拠

ORDレコード
ord-712fec2504a749cfa2b8a87ad88f1ffa
出典データセット
uspto-grants-1989_05
特許番号
US04826977

反応ノート

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