Aluminum(III) Chloride → 2,3-Dichloro-4-hydroxy-N-n-butylaniline

HRID 1761667

反応式

HRID 1761667 の反応式
[Cl:1][C:2]1[C:12]([Cl:13])=[C:11]([O:14]C)[CH:10]=[CH:9][C:3]=1[NH:4][CH2:5][CH2:6][CH2:7][CH3:8].[Cl-].[Al+3].[Cl-].[Cl-]>ClC(Cl)C(Cl)Cl>[Cl:1][C:2]1[C:12]([Cl:13])=[C:11]([OH:14])[CH:10]=[CH:9][C:3]=1[NH:4][CH2:5][CH2:6][CH2:7][CH3:8]

参加物

4

反応物 2

HCID 6451240Aluminum(III) ChlorideHCID 136884512,3-Dichloro-4-methoxy-N-n-butylaniline

生成物 1

HCID 198144102,3-Dichloro-4-hydroxy-N-n-butylaniline

試薬・触媒・溶媒 1

HCID 65911,1,2,2-Tetrachloroethane溶媒

実験手順

To a stirred solution of 2,3-dichloro-4-methoxy-N-n-butylaniline (8.5 g) in 1,1,2,2-tetrachloroethane (80 ml) is added anhydrous aluminium chloride (8.5 g), and the mixture is refluxed for about 40 hours. The resulting mixture is poured into ice/water (about 500 ml), and the precipitated material is extracted twice with methylene chloride. The combined extracts are dried and evaporated in vacuo to give the title compound as a heavy oil.

後処理

  1. temperaturethe mixture is refluxed for about 40 hours
  2. extractionthe precipitated material is extracted twice with methylene chloride
  3. customThe combined extracts are dried
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-8388fbe10957459ba1e0699610d265f6
出典データセット
uspto-grants-1989_05
特許番号
US04826987

関連ノート

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