Bromine → HCID 14125892、化合物

HRID 1761890ノート

反応式

HRID 1761890 の反応式
[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]([CH2:15][CH2:16][CH2:17][Cl:18])=[O:14])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:19]Br>C(O)(=O)C>[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]([CH:15]([Br:19])[CH2:16][CH2:17][Cl:18])=[O:14])=[CH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 24408BromineHCID 122875581-Butanone, 1-[1,1'-biphenyl]-4-yl-4-chloro-

生成物 1

HCID 14125892HCID 14125892、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

246 g (0.95 mol) of 3-chloropropyl 4-phenylphenyl ketone in 380 ml of glacial acetic acid were placed in a reaction flask and 152 g (0.95 mol) of bromine were added dropwise at 30° C., the reaction commencing with dissolution and decolorization. After 1 hour, a thick precipitate deposited. The mixture was stirred for a further 4 hours at room temperature in order to complete the reaction. The crystals produced were filtered off under suction, washed with water, dissolved in dichloromethane, washed by shaking with NaHCO3 solution and water and dried, and 250 g (78% of theory) of the title substance were obtained as colorless crystals of melting point 85°-88° C.

後処理

  1. dissolutionthe reaction commencing with dissolution and decolorization
  2. customthe reaction
  3. customThe crystals produced
  4. filtrationwere filtered off under suction
  5. washwashed with water
  6. dissolutiondissolved in dichloromethane
  7. washwashed
  8. stirringby shaking with NaHCO3 solution and water
  9. customdried
  10. custom250 g (78% of theory) of the title substance were obtained as colorless crystals of melting point 85°-88° C.

出典と根拠

ORDレコード
ord-8667b01de8eb4dc28a469c06b315aa42
出典データセット
uspto-grants-1989_05
特許番号
US04829075

反応ノート

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