Hydrochloric Acid → 2-(4-Nitrophenyl)benzofuran-7-carboxylic acid

HRID 1761926ノート

反応式

HRID 1761926 の反応式
[CH:1]([C:3]1[C:4]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=2)=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([O:8]C)=[O:7])=O.C[O-].[Na+].Cl>CN(C)C=O.CO>[N+:21]([C:18]1[CH:19]=[CH:20][C:15]([C:14]2[O:13][C:4]3[C:5]([C:6]([OH:8])=[O:7])=[CH:10][CH:11]=[CH:12][C:3]=3[CH:1]=2)=[CH:16][CH:17]=1)([O-:23])=[O:22]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 10942334Sodium MethoxideHCID 20043641Methyl 3-formyl-2-(4-nitrobenzyloxy)benzoate

生成物 1

HCID 142297282-(4-Nitrophenyl)benzofuran-7-carboxylic acid収率 59.8%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6228Dimethylformamide溶媒

実験手順

16.1 g of methyl 3-formyl-2-(4-nitrobenzyloxy)benzoate are dissolved in 100 ml of dimethylformamide and a solution of 5.4 g of sodium methoxide in 20 ml of methanol is added dropwise to the solution at 120° C. The mixture is stirred at the same temperature for 10 minutes. The reaction mixture is acidified with 10% hydrochloric acid and then extracted with ethyl acetate. The extract is washed with water, dried and evaporated to remove solvent. The resultant crystals are collected, washed and dried to give 8.65 g of 2-(4-nitrophenyl)benzofuran-7-carboxylic acid as pale orange powder.

後処理

  1. extractionextracted with ethyl acetate
  2. washThe extract is washed with water
  3. customdried
  4. customevaporated
  5. customto remove solvent
  6. customThe resultant crystals are collected
  7. washwashed
  8. customdried

出典と根拠

ORDレコード
ord-311ff26f9dfc4930a329f93cf2b18c57
出典データセット
uspto-grants-1989_05
特許番号
US04829067

反応ノート

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