1,4-Naphthoquinone → Mitoquidone

HRID 1762110ノート

反応式

HRID 1762110 の反応式
[CH:1]([N:3]1[CH:12]([C:13](O)=O)[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4]1)=O.[C:16]1(=[O:27])[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:19](=[O:26])[CH:18]=C1>C(OC(=O)C)(=O)C>[CH:9]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:10]=1[CH2:11][C:12]1[N:3]([CH:1]=[C:18]3[C:13]=1[C:16](=[O:27])[C:25]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:19]3=[O:26])[CH2:4]2

参加物

4

反応物 2

HCID 85301,4-NaphthoquinoneHCID 123241712-Formyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

生成物 1

HCID 71772Mitoquidone

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

反応条件

温度
100 °C

実験手順

A mixture of 2-formyl-3-carboxy-1,2,3,4-tetrahydroisoquinoline (20 g) and 1,4-naphthoquinone (30.8 g) in acetic anhydride (500 ml) was heated at 100° C. with stirring for 30 minutes. The reaction mixture was cooled, the solid collected by filtration, washed with acetic anhydride (50 g) with ether (2×100ml) and dried to give the title compound in Form B (26 g).

後処理

  1. temperatureThe reaction mixture was cooled
  2. filtrationthe solid collected by filtration
  3. washwashed with acetic anhydride (50 g) with ether (2×100ml)
  4. customdried

出典と根拠

ORDレコード
ord-3e6c57dee69d483db1b29de38c740d3c
出典データセット
uspto-grants-1989_05
特許番号
US04831039

反応ノート

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