HCID 14368366、化合物 → HCID 14368376、化合物
反応式
C([O:3][C:4]([C:6]1[CH:26]=[CH:25][C:9]([CH2:10][O:11][C:12]2[C:13]3[N:14]([C:18]([CH2:22][C:23]#[CH:24])=[C:19]([CH3:21])[N:20]=3)[CH:15]=[CH:16][CH:17]=2)=[CH:8][CH:7]=1)=[O:5])C>C(O)C.S(=O)(=O)(O)O>[C:4]([C:6]1[CH:7]=[CH:8][C:9]([CH2:10][O:11][C:12]2[C:13]3[N:14]([C:18]([CH2:22][C:23]#[CH:24])=[C:19]([CH3:21])[N:20]=3)[CH:15]=[CH:16][CH:17]=2)=[CH:25][CH:26]=1)([OH:5])=[O:3]参加物
4
実験手順
A mixture of 8-(4-ethoxycarbonylbenzyloxy)-2-methyl-3-(2-propynyl)imidazo[1,2-a]pyridine (1.04 g) in ethanol (15 ml) and 20% sulfuric acid (40 ml) was refluxed for 5 hours and then ethanol was evaporated in vacuo. The mixture was cooled and the resulting precipitates were collected by filtration. The obtained sulfate was treated with an aqueous solution of sodium bicarbonate and then the mixture was adjusted to pH 4.5 with acetic acid. The resulting precipitates were collected by filtration and air-dried to give 8-(4-carboxybenzyloxy)-2-methyl-3-(2-propynyl)imidazo[1,2-a]pyridine (0.66 g).