Hydrochloric Acid → HCID 20042545、化合物
反応式
[OH:1][CH2:2][C:3]1[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][OH:25])[C:4]=1[CH2:5][O:6][C:7]1[C:8]2[N:9]([C:13]([CH2:17][C:18]#[CH:19])=[C:14]([CH3:16])[N:15]=2)[CH:10]=[CH:11][CH:12]=1.[ClH:26]>CO>[ClH:26].[OH:25][CH2:24][C:20]1[CH:21]=[CH:22][CH:23]=[C:3]([CH2:2][OH:1])[C:4]=1[CH2:5][O:6][C:7]1[C:8]2[N:9]([C:13]([CH2:17][C:18]#[CH:19])=[C:14]([CH3:16])[N:15]=2)[CH:10]=[CH:11][CH:12]=1参加物
4
実験手順
To a suspension of 8-[2,6-bis(hydroxymethyl)benzyloxy]-2-methyl-3-(2-propynyl)imidazo[1,2-a]pyridine (4.9 g) in methanol (80 ml) was added 1 N hydrochloric acid (15 ml) at room temperature. The obtained clear solution was concentrated under reduced pressure and the residue was recrystallized from a mixture of acetone (100 ml) and water (8 ml) to give 8-[2,6-bis(hydroxymethyl)benzyloxy]-2-methyl-3-(2-propynyl)imidazo[1,2-a]pyridine hydrochloride (4.44g)
後処理
- concentration