Hydrochloric Acid → HCID 20043143、化合物

HRID 1762291ノート

反応式

HRID 1762291 の反応式
[CH3:1][NH:2][C:3]1[CH2:4][O:5][C:6]2[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=2[C:8](=[O:10])[CH:9]=1.[ClH:15]>CO>[ClH:15].[CH3:1][NH:2][C:3]1[CH2:4][O:5][C:6]2[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=2[C:8](=[O:10])[CH:9]=1

参加物

4

反応物 2

HCID 313Hydrochloric Acid2 回HCID 134460473-(Methylamino)-1-benzoxepin-5(2H)-one

生成物 1

HCID 20043143HCID 20043143、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

19 g 3-methylamino-1-benzoxepin-5(2H)-one were suspended in 130 ml methanol, and gaseous hydrogen chloride was introduced into the suspension with stirring in order to convert it into its hydrochloride. The amine thereby goes into solution with warming. Subsequently approximately 40 ml methanol were distilled from the solution. The solution was allowed to stand to crystallize the hydrochloride which was formed, and the crystals which formed were removed by filtration. 22 g 3-methylamino-1-benzoxepin-5(2H)-one hydrochloride were obtained which were used without further purification in the following hydrogenation.

後処理

  1. temperaturewith warming
  2. distillationSubsequently approximately 40 ml methanol were distilled from the solution
  3. customto crystallize the hydrochloride which
  4. customwas formed
  5. customthe crystals which formed
  6. customwere removed by filtration

出典と根拠

ORDレコード
ord-a205a25a394b419c90fc37aa46f536ef
出典データセット
uspto-grants-1989_05
特許番号
US04831167

反応ノート

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