Phosphorus oxychloride → 3-(Trifluoromethyl)phenylmethanesulfonyl chloride

HRID 1762297

反応式

HRID 1762297 の反応式
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[CH2:6][S:7]([O-])(=[O:9])=[O:8].[Na+].P(Cl)(Cl)([Cl:19])=O>>[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[CH2:6][S:7]([Cl:19])(=[O:9])=[O:8]

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 23700704Sodium 3-trifluoromethylbenzylsulfonate

生成物 1

HCID 27946463-(Trifluoromethyl)phenylmethanesulfonyl chloride収率 90.2%

実験手順

10 g of sodium 3-trifluoromethylbenzylsulfonate was slowly added to 17.7 ml (29.1 g) of phosphorous oxychloride. The resulting slurry was stirred at 100° to 105° C. for five hours. The reaction mixture was then cooled and filtered. The filter cake was washed with methylene chloride, the washings were combined with the filtrate and then evaporated to dryness affording 8.9 g of 3-trifluoromethylbenzylsulfonyl chloride.

後処理

  1. temperatureThe reaction mixture was then cooled
  2. filtrationfiltered
  3. washThe filter cake was washed with methylene chloride
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-dda8beac658d4adba47334e9624a3721
出典データセット
uspto-grants-1989_05
特許番号
US04831179

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