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(1R)-1-(3-phenoxyphenyl)ethan-1-ol → 2,2-Dimethyl-3-(3-cyclopropylmethoxy-3-oxo-1-propenyl) cyclopropane-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (1R)-1-(3-phenoxyphenyl)ethan-1-ol | HCID 22815813 | — |
| 反応物 | 2,2-Dimethyl-3-(3-cyclopropylmethoxy-3-oxo-1-propenyl) cyclopropane-carboxylic acid | HCID 53915596 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 2,2-Dimethyl-3-(3-cyclopropylmethoxy-3-oxo-1-propenyl) cyclopropane-carboxylic acid | HCID 53915596 | — |
| 生成物 | 2,2-Dimethyl-3-(3-cyclobutoxy-3-oxo-1-propenyl)-cyclopropane-carboxylate | HCID 73675571 | — |
反応手順
Using the procedure of Example 9, (1R, cis ΔZ) 2,2-dimethyl-3-(3-cyclobutoxy-3-oxo-1-propenyl)-cyclopropane-carboxylic acid and 1(R)-(3-phenoxy-phenyl)-ethanol were reacted to obtain 1(R)-(3-phenoxy-phenyl)-ethyl (1R, cis, ΔZ) 2,2-dimethyl-3-(3-cyclobutoxy-3-oxo-1-propenyl)-cyclopropane-carboxylate with a specific rotation of [α]D20 =+125.5°±2° (c=1% in chloroform).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04833163 |
| 出典データセット | uspto-grants-1989_05 |
| ORD ID | ord-6c1f19492d284e72bbba6e1480e15afb |
| 出典メモ | uspto-grants-1989_05 |