Diethyl Ether → 1-(4-Bromobutyldimethylsilyl)-1-propyne
反応式
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][Si:6]([CH3:9])([CH3:8])Cl.[C:10]([Li])#[C:11]C.[CH2:14](OCC)C>>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][Si:6]([CH3:9])([CH3:14])[C:8]#[C:10][CH3:11]参加物
4
反応条件
- 温度
- 25 °C
実験手順
This novel monomer was synthesized by adding 6.7 g (0.029 mole) of 4-bromobutyldimethylchlorosilane dropwise at 0° C. to a stirred solution of propynyllithium (1.34 g, 0.029 mole) in 50 ml of dry diethyl ether. The reaction mixture was stirred overnight at 25° C. and then poured into 400 ml of ice water. The ether layer was washed with distilled water, separated, and dried over MgSO4. The ether layer was then filtered and the product separated by removing the ether using a rotovapor. The resulting oil was purified by vacuum distillation and had a b.p. of 70°-75° C. at 15 mm Hg pressure. Yield was 75% of theoretical. 'H NMR confirmed the structure.
後処理
- customThis novel monomer was synthesized
- washThe ether layer was washed with distilled water
- customseparated
- dry with materialdried over MgSO4
- filtrationThe ether layer was then filtered
- customthe product separated
- customby removing the ether using a rotovapor
- distillationThe resulting oil was purified by vacuum distillation
出典と根拠
- ORDレコード
- ord-f00bb330070343ccbab9ad1a25432498
- 出典データセット
- uspto-grants-1989_05
- 特許番号
- US04833262
反応ノート
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