Ammonia → 4-(1-Acetylpiperidin-4-yl)benzenesulphonamide

HRID 1762838ノート

反応式

HRID 1762838 の反応式
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:15]=[CH:14][C:13]([S:16](Cl)(=[O:18])=[O:17])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[NH3:20]>C(O)C>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:15]=[CH:14][C:13]([S:16]([NH2:20])(=[O:18])=[O:17])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 222AmmoniaHCID 200398204-(1-Acetylpiperidin-4-yl)benzenesulphonyl chloride

生成物 1

HCID 200398334-(1-Acetylpiperidin-4-yl)benzenesulphonamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The product of (i) above (21.0 g) was added portionwise to a stirred mixture of concentrated aqueous ammonia solution (160 ml) and ethanol (160 ml). The mixture was warmed at 35° until solution was complete and then evaporated. The residue was triturated with water and the solid was filtered off and dried to give the title compound, (18.0 g), m.p. 196°-197° (from ethanol).

後処理

  1. temperatureThe mixture was warmed at 35° until solution
  2. customevaporated
  3. customThe residue was triturated with water
  4. filtrationthe solid was filtered off
  5. customdried

出典と根拠

ORDレコード
ord-72a4f3b0303c4c06ac9a418e5d4a246f
出典データセット
uspto-grants-1989_05
特許番号
US04835165

反応ノート

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