4-(1-Acetylpiperidin-4-yl)benzenesulphonamide → 4-Piperidin-4-YL-benzenesulfonamide

HRID 1762839ノート

反応式

HRID 1762839 の反応式
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:15]=[CH:14][C:13]([S:16]([NH2:19])(=[O:18])=[O:17])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=O)C>Cl>[NH:4]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:15]=[CH:14][C:13]([S:16]([NH2:19])(=[O:17])=[O:18])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1

参加物

3

反応物 1

HCID 200398334-(1-Acetylpiperidin-4-yl)benzenesulphonamide

生成物 1

HCID 183484304-Piperidin-4-YL-benzenesulfonamide

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A mixture of the product of part (ii) above (17.0 g) and 5N aqueous hydrochloric acid (150 ml) was heated under reflux for 3 hours. The resulting solution was evaporated and the residue was dissolved in the minimum volume of water. The solution was made basic (to a pH of about 8-9) by the addition of solid sodium bicarbonate. The solid was filtered off, washed with a little water and crystallised from ethanol/methanol (2:1) to give the title compound, (7.70 g), m.p. 229°-230°.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hours
  3. customThe resulting solution was evaporated
  4. dissolutionthe residue was dissolved in the minimum volume of water
  5. additionby the addition of solid sodium bicarbonate
  6. filtrationThe solid was filtered off
  7. washwashed with a little water
  8. customcrystallised from ethanol/methanol (2:1)

出典と根拠

ORDレコード
ord-5746187191b3472e876e9aa341aac1a1
出典データセット
uspto-grants-1989_05
特許番号
US04835165

反応ノート

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